Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis†,10.1039/D2CC04102B

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis†

Viral Rawat,Sona Tiwari,Shweta Khanna,Umang Gupta,Sridhar S. N. C.,Dharmendra K. Yadav,Abdul Akhir,Deepanshi Saxena,Saravanan Matheshwaran,Dharmaraja Allimuthu

Chemical Communications Pub Date : 09/16/2022 00:00:00 , DOI:10.1039/D2CC04102B

Abstract

Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3H)-one (IITK2020), an exclusive S. aureus inhibitor at 2–4 μg mL⁻¹ MIC including multidrug-resistant S. aureus clinical strains, that prevents peptidoglycan biosynthesis.