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Au(iii)-catalyzed intermolecular amidation of benzylic C–H bonds†
Bainian Feng,Chengjian Zhu
Organic & Biomolecular Chemistry Pub Date : 10/16/2012 00:00:00 , DOI:10.1039/C2OB26857D
Abstract

Au(III)-catalyzed intermolecular amidations of benzylic C–H bonds with sulfonamides and carboxamides are described. The protocol with the Au–bipy complex/N-bromosuccinimide system provides practical applications for synthesis of various amides via C–H activations. The reaction proceeds with high efficiency to give the corresponding amines, which are extremely useful synthetic intermediates.

Graphical abstract: Au(iii)-catalyzed intermolecular amidation of benzylic C–H bonds
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