Stable high-oxidation-state complex in situ Mn(v)–Mn(iii) transition to achieve highly efficient cervical cancer therapy†,10.1039/D1CC06819A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Stable high-oxidation-state complex in situ Mn(v)–Mn(iii) transition to achieve highly efficient cervical cancer therapy†

Hanjie Zhang,Yuequn Zhang,Jianrong Cao,Li Ma,Tianfeng Chen

Chemical Communications Pub Date : 02/01/2022 00:00:00 , DOI:10.1039/D1CC06819A

Abstract

Designing metal complexes to target the vulnerable redox balance in cancer cells is a promising strategy to realize successful cancer therapy. The synthesized stable nitridomanganese(V) complex Mn^V(N) (salen) not only reacts with GSH to achieve in situ Mn(V)–Mn(III) transformation to down-regulate the antioxidant system, but also catalyzes H₂O₂ to higher oxidation capacity ROS to up-regulate the intracellular oxidative level, finally resulting in cancer cell death.