A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins†,10.1039/C3CC44647F

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A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins†

Paul C. Taylor,Andrew J. Clark,Andrew Marsh,Donald R. J. Singer,Suzanne J. Dilly

Chemical Communications Pub Date : 09/02/2013 00:00:00 , DOI:10.1039/C3CC44647F

Abstract

Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death.