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Practical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides†
Aki Miyoshi,Yasuaki Miyazaki,Shigeki Kubo
Chemical Communications Pub Date : 04/25/2022 00:00:00 , DOI:10.1039/D2CC01105K
Abstract

We have found that the etherification of silyl-protected secondary alcohols proceeds smoothly in the presence of strontium metal using silyl chloride instead of the expensive, yet more reactive, and commonly used silyl triflate. The reaction occurred almost completely with various alcohols.

Graphical abstract: Practical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides
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