Harnessing the dual antimicrobial mode of action with a lipophilic Mn(ii) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous†,10.1039/D3DT01904G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Harnessing the dual antimicrobial mode of action with a lipophilic Mn(ii) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous†

Bijaya Bagale,Guanyu Chen,Jeanette A. Krause,Jeffrey D. Mighion,Songping D. Huang

Dalton Transactions Pub Date : 08/16/2023 00:00:00 , DOI:10.1039/D3DT01904G

Abstract

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn(II) ionophore results in the synthesis of Mn(BQ)₂(DMSO)₂·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL⁻¹). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.