Transition metal-free photocatalytic radical annulation of 2-cyanoaryl acrylamides with difluoromethyl radicals to assemble 4-amino-quinolinone derivatives†,10.1039/D3GC02132G

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Transition metal-free photocatalytic radical annulation of 2-cyanoaryl acrylamides with difluoromethyl radicals to assemble 4-amino-quinolinone derivatives†

Qiaoyan Wu,Niuniu Zhang,Xirui Gong,Meilin Ren,Yanli Xu,Yanyan Chen

Green Chemistry Pub Date : 07/21/2023 00:00:00 , DOI:10.1039/D3GC02132G

Abstract

The transformation of an iminyl radical into a primary amine is a challenging task. A practical and green catalytic system to trigger difluoromethyl radicals is highly desired. Herein, we developed a metal-free photocatalytic radical annulation of 2-cyanoaryl acrylamides with [CF₂HPPh₃]⁺Br⁻ to provide 4-amino-quinolinones in moderate to good yields. This protocol utilized an easily obtained and cheap organophotocatalyst and green solvent acetone/H₂O, and had the advantages of simple operation and broad substrate scope.