Knoevenagel condensation is widely used in organic synthetic chemistry and several reaction conditions have been demonstrated. These reactions in neutral medium are challenging. In this report, we present a sustainable and greener method for Knoevenagel condensation reaction between carbonyl compounds (both aldehydes and ketones) and active methylene compounds using rose bengal as a photosensitizer in an aqueous medium. This protocol works smoothly for aromatic aldehydes and ketones containing both electron-donating and electron-withdrawing substituents.