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Asymmetric syntheses of enantiopure C(5)-substituted transpentacins via diastereoselective Ireland–Claisen rearrangements†
Stephen G. Davies,Ai M. Fletcher,Paul M. Roberts,James E. Thomson,Charlotte M. Zammit
Chemical Communications Pub Date : 06/27/2013 00:00:00 , DOI:10.1039/C3CC43250E
Abstract

Asymmetric syntheses of (S,S,S)-2-amino-5-methylcyclopentanecarboxylic acid and (S,S,S)-2-amino-5-phenylcyclopentanecarboxylic acid were achieved in 9 steps from commercially available starting materials via the Ireland–Claisen rearrangement of two enantiopure β-amino allyl esters, followed by ring-closing metathesis, reduction and deprotection.

Graphical abstract: Asymmetric syntheses of enantiopure C(5)-substituted transpentacins via diastereoselective Ireland–Claisen rearrangements
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