Stabilizing Pickering emulsions with solid catalysts at the oil–water interface is one of the most effective ways to develop environmentally friendly chemical processes. In this study, metal–organic frameworks (ZIF-8, UiO-66(Zr)-NH₂, and MIL-101(Cr)-NH₂) with both Lewis acid and Brønsted base sites were synthesized to prepare Pickering emulsions to catalyse the deacetalization-Knoevenagel tandem reaction. Most importantly, the Pickering emulsion stabilized with ZIF-8 showed the highest catalytic activity and maintained good chemical stability. What is more, the spent Pickering emulsion could be easily reconstructed and it showed good reusability even after five cycles.