Annulation of α-bromocinnamaldehydes to access 3-formyl-imidazo[1,2-α]pyridines and pyrimidines under transition metal-free conditions†,10.1039/D3OB00695F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Annulation of α-bromocinnamaldehydes to access 3-formyl-imidazo[1,2-α]pyridines and pyrimidines under transition metal-free conditions†

Fanglian Zhang,Jiameng Liu,Wenjun Luo,Yuping Zhu,Yi Xiao,Shuxian Ma,Zhengwang Chen

Organic & Biomolecular Chemistry Pub Date : 05/29/2023 00:00:00 , DOI:10.1039/D3OB00695F

Abstract

An environmentally friendly and transition metal-free method for the annulation of α-bromocinnamaldehydes was established. 3-Formyl-imidazo[1,2-α]pyridines and pyrimidines were obtained in moderate to excellent yields. This approach features easily available starting materials, transition metal-free conditions, good functional group tolerance and operational simplicity.