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Total synthesis of both enantiomers of the biosurfactant aureosurfactin via bidirectional synthesis with a chiral Horner–Wittig building block†
Fabia Mittendorf,Moritz Quambusch,Stefan F. Kirsch
Organic & Biomolecular Chemistry Pub Date : 05/24/2023 00:00:00 , DOI:10.1039/D3OB00650F
Abstract

Aureosurfactin is a novel biosurfactant that exhibits similar surface tension activity to known biosurfactants. In this work, we now report a facile synthesis for aureosurfactin using a bidirectional synthetic strategy. Both enantiomers of the target compound were accessed from the (S)-building block, derived from the same chiral pool starting material.

Graphical abstract: Total synthesis of both enantiomers of the biosurfactant aureosurfactin via bidirectional synthesis with a chiral Horner–Wittig building block
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