Ruthenium(ii)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones – insights into additive-controlled product selectivity†,10.1039/D3OB00297G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Ruthenium(ii)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones – insights into additive-controlled product selectivity†

Alagumalai Ramkumar,Ramdas Sreedharan,Purushothaman Rajeshwaran,Thirumanavelan Gandhi

Organic & Biomolecular Chemistry Pub Date : 02/27/2023 00:00:00 , DOI:10.1039/D3OB00297G

Abstract

Herein, we developed ruthenium(II)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones. The product selectivity is controlled by the additives, and the hydroarylated product was obtained in water, which is an important highlight of this study. Control experiments were conducted to elucidate a plausible mechanism. These experiments suggest the occurrence of an oxidative dehydrogenation pathway over E2-type elimination – the key step in producing Heck-type products.