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Synthesis of axially chiral N-aryl benzimidazoles via chiral phosphoric acid catalyzed enantioselective oxidative aromatization†
Jin-fang Chen,Jin-yi Shi,Cong-cong Yin,Xin Cui,Guang-xun Li,Zhuo Tang,Jin-zhong Zhao
New Journal of Chemistry Pub Date : 03/16/2022 00:00:00 , DOI:10.1039/D1NJ06092A
Abstract

Given the great importance of N-substituted benzimidazoles in pharmaceutics, here N-aryl benzimidazoline produced in situ was used as a H2 donor, which was converted to C–N axially chiral N-aryl benzimidazole by CPA-catalyzed enantioselective transfer hydrogenation of the in situ produced imine.

Graphical abstract: Synthesis of axially chiral N-aryl benzimidazoles via chiral phosphoric acid catalyzed enantioselective oxidative aromatization
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