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Aluminium-catalysed synthesis of aryl enol ethers from phenols and dimethyl ketals†
Kwihwan Kobayashi,Shingo Komatsuzaki,Shun-ya Onozawa,Koichiro Masuda
Organic & Biomolecular Chemistry Pub Date : 09/05/2023 00:00:00 , DOI:10.1039/D3OB01266B
Abstract

We report an environmentally friendly, aluminium-catalysed, halide- and transition metal-free method for the synthesis of aryl enol ethers from phenols and dimethyl ketals that involves ketal exchange driven by the removal of methanol. The obtained aryl enol ethers were transformed into the corresponding diaryl ethers by Pd/C-catalysed dehydrogenation or DDQ oxidation.

Graphical abstract: Aluminium-catalysed synthesis of aryl enol ethers from phenols and dimethyl ketals
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