Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSO2CF2CO2Me and Et3N·3HF†
Song Zou,Xuewei Luo,Chao Chen
Organic & Biomolecular Chemistry Pub Date : 04/14/2022 00:00:00 , DOI:10.1039/D2OB00488G
Abstract

Photoredox-catalyzed three-component fluorodifluoroacetylation of aromatic alkenes is reported, which features a wide substrate scope and functional group tolerance. An advantage of the reaction is the use of a nucleophilic fluoride source and a general difluoroacetylation reagent for the fluorodifluoroacetylation of alkenes.

Graphical abstract: Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSO2CF2CO2Me and Et3N·3HF