One-pot synthesis of 1,3-oxazin-4-ones through an Ir-catalyzed mild formal condensation reaction of secondary amides with acyl chlorides†,10.1039/D3QO00092C

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

One-pot synthesis of 1,3-oxazin-4-ones through an Ir-catalyzed mild formal condensation reaction of secondary amides with acyl chlorides†

Si-Jia Yu,Jie Li,Jian-Liang Ye,Pei-Qiang Huang

Organic Chemistry Frontiers Pub Date : 03/06/2023 00:00:00 , DOI:10.1039/D3QO00092C

Abstract

A facile and efficient synthesis of bicyclic 1,3-oxazin-4-ones, 2,3,6,7-tetrahydrocyclopenta[e]-1,3-oxazin-4-ones and 2,3,5,6,7,8-hexahydro-4H-benzo[e]-1,3-oxazin-4-ones, has been achieved via an Ir-catalyzed one-pot reaction of secondary amides with adipoyl chloride and pimeloyl chloride, respectively. This method features good yields, broad substrate scope, mild reaction conditions, and scalability. This reaction also shows good compatibility with acetyl chloride and phenylacetyl chloride to access monocyclic 1,3-oxazin-4-ones.