Cascade Michael/aldol/rearrangement between phenacylmalononitriles and maleimides: highly diastereoselective access to functionalized bicyclic cyclopentenes containing a CN-substituted all-carbon quaternary center†‡,10.1039/D1QO01762D

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Cascade Michael/aldol/rearrangement between phenacylmalononitriles and maleimides: highly diastereoselective access to functionalized bicyclic cyclopentenes containing a CN-substituted all-carbon quaternary center†‡

Li Gao,Gaihui Li,Xiaokang Li,Guoshun Zhang,Min Zhang,Shurong Ban

Organic Chemistry Frontiers Pub Date : 03/19/2022 00:00:00 , DOI:10.1039/D1QO01762D

Abstract

Annulation of phenacylmalononitriles with maleimides offers a highly diastereoselective synthesis of unprecedented multifunctionalized bicyclic cyclopentenes containing a CN-substituted all-carbon quaternary center. Experimental and theoretical studies revealed that the reaction likely involves a Michael/aldol/rearrangement sequence in a domino manner.