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gem-Bromonitrocyclobutane induced radical cyclization of acrylanilides to construct 2-oxindoles via photoredox catalysis†
Yawen Guo,Shanshan Ma,Lin Shi,Lidong Liu,Xingyu Lei,Peng Jiao
Organic Chemistry Frontiers Pub Date : 03/30/2023 00:00:00 , DOI:10.1039/D3QO00181D
Abstract

A mild and efficient method involving tandem radical reactions of gem-bromonitroalkanes with various acrylanilides is reported. 2-Oxindoles with a 1-nitrocyclobutyl unit, otherwise hard to prepare, were easily obtained in good yields. The visible light induced generation of the α-nitroalkyl radical was a key step to initiate the reaction.

Graphical abstract: gem-Bromonitrocyclobutane induced radical cyclization of acrylanilides to construct 2-oxindoles via photoredox catalysis
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