Palladium-catalyzed desulfonylative aminocarbonylation of benzylsulfonyl chlorides with o-aminobenzaldehydes/o-aminoacetophenones for the synthesis of quinoin-2(1H)-ones†,10.1039/D2QO01370C

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Palladium-catalyzed desulfonylative aminocarbonylation of benzylsulfonyl chlorides with o-aminobenzaldehydes/o-aminoacetophenones for the synthesis of quinoin-2(1H)-ones†

Weiqi Dai,Ren-Guan Miao,Ruyi Zhao,Xinxin Qi

Organic Chemistry Frontiers Pub Date : 09/21/2022 00:00:00 , DOI:10.1039/D2QO01370C

Abstract

A straightforward and efficient synthesis of quinoin-2(1H)-ones has been explored via a palladium-catalyzed desulfonylative aminocarbonylation of benzylsulfonyl chlorides with o-aminobenzaldehydes/o-aminoacetophenones. With benzylsulfonyl chlorides as the C(sp³) electrophiles, a variety of quinoin-2(1H)-ones were obtained in moderate to high yields.