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Stereo-divergent synthesis of silyl-enyne via palladium-catalyzed coupling of alkynes and iodosilanes†
Kun-Long Song,Bin Wu,Wan-Er Gan,Yan Zeng,Yu-Jie Zhang,Jian Cao
Organic Chemistry Frontiers Pub Date : 05/27/2022 00:00:00 , DOI:10.1039/D2QO00622G
Abstract

We report a palladium-catalyzed coupling reaction of alkynes and silicon electrophiles, affording stereodefined silyl-enynes. Either E- or Z-enynes can be formed in high yields and in a highly stereoselective manner depending on the choice of ligands.

Graphical abstract: Stereo-divergent synthesis of silyl-enyne via palladium-catalyzed coupling of alkynes and iodosilanes
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