Mesoporous silica is restricted to organic solvents or other acidic media. The application of mesoporous silica depends on the medium's chemical stability and mechanical properties. It is necessary to stabilize the mesoporous silica material under acidic conditions. The results of the nitrogen adsorption characterization show that MS-50 has a large surface area and porosity, resulting in good mesoporous silica. Using variance analysis (ANOVA) to compare the collected data, the best conditions were found at a pH of 6.32, a Cd²⁺ concentration of 25.30 ppm, an adsorbent dose of 0.06 g, and a time of 70.44 min. The Cd²⁺ adsorption experiment data best fit the Langmuir isotherm model with the maximum amount of Cd²⁺ that MS-50 could absorb being 103.10 mg g⁻¹.