Transition metal catalyzed Sonogashira coupling reaction has evolved as an efficient pathway for the construction of C–C bonds. Initially, palladium cooperating with copper was considered as the efficient catalytic system for this reaction. However, nowadays there have been astonishing progress in copper catalyzed Sonogashira coupling reactions. Copper catalyzed reactions have attained significant attention owing to the cost effective and environmentally benign characteristics of this metal compared to palladium. This review summarizes the recent developments in copper catalyzed Sonogashira coupling covering literature from 2014 to 2021.