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A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues†
V. Krishna Reddy,G. Nageswara Rao,K. Basavaiah,Kalyan C. Nagulapalli Venkata
RSC Advances Pub Date : 01/18/2023 00:00:00 , DOI:10.1039/D2RA06341G
Abstract

We developed a novel one-pot strategy for synthesizing biologically important 1,2,4-triazole motifs from easily accessible 4-hydroxy phenylacetic acid, formamidine hydrochloride and hydrazine derivatives under mild conditions. This strategy enabled us to synthesize the natural penipanoid A and its analogues in one step.

Graphical abstract: A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues
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