A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin†,10.1039/D2RA01385A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A concise and efficient total synthetic route of active stilbene dimer (±)-ε-viniferin†

Qibin Zhu,Binhao Teng,Ying Chen,Fubao Su,Yanqiu Li,Qingyun Yang,Chunsuo Yao

RSC Advances Pub Date : 04/08/2022 00:00:00 , DOI:10.1039/D2RA01385A

Abstract

A concise and efficient procedure for the total synthesis of natural stilbene dimer (±)-ε-viniferin was accomplished with high overall yield. Demethylation of the key intermediate methyl 3-arylbenzofuran-4-carboxylate was achieved successfully through bromination followed by BBr₃-or BCl₃/TBAI-mediated ether cleavage reaction. Pd/C and bromobenzene-catalyzed MOM ether cleavage was successfully carried out to aquire (±)-ε-viniferin.