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Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies†
Jin Huang,Teresa Mena-Barragán,Carmen Ortiz Mellet,Camille Decroocq,Emile Etamé,Andreas Heise
Chemical Communications Pub Date : 02/07/2014 00:00:00 , DOI:10.1039/C3CC48190E
Abstract

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

Graphical abstract: Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies
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