Total synthesis of ascididemin via anionic cascade ring closure†
Ida Nymann Petersen,François Crestey,Jesper Langgaard Kristensen
Chemical Communications Pub Date : 07/23/2012 00:00:00 , DOI:10.1039/C2CC34725C
Abstract
A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2′-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.
