Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex†
Meng Zhao,Han-Lu Wang,Li Zhang,Cunyuan Zhao,Liang-Nian Ji,Zong-Wan Mao
Chemical Communications Pub Date : 06/03/2011 00:00:00 , DOI:10.1039/C1CC12466H
Abstract
A surprisingly low pKa (4.3) for a Cu(II) bridging water was found in the presented complex, Cu22L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn22L at typical lysosomal pH (∼5.0).
