Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen†,10.1039/C1CC10763A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen†

Timothy J. Woodman,Pauline J. Wood,Andrew S. Thompson,Thomas J. Hutchings,Georgina R. Steel,Ping Jiao,Michael D. Threadgill,Matthew D. Lloyd

Chemical Communications Pub Date : 05/26/2011 00:00:00 , DOI:10.1039/C1CC10763A

Abstract

Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; ‘profens’), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.