Efficient access to a dihydropyran-containing macrolidevia a transannular oxy-Michael reaction: total synthesis of (+)-aspergillide C†,10.1039/C1CC12114F

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Efficient access to a dihydropyran-containing macrolidevia a transannular oxy-Michael reaction: total synthesis of (+)-aspergillide C†

Hisataka Kobayashi,Makoto Kanematsu,Masahiro Yoshida,Kozo Shishido

Chemical Communications Pub Date : 05/31/2011 00:00:00 , DOI:10.1039/C1CC12114F

Abstract

The second-generation enantioselective total synthesis of aspergillide C, a new type of 14-membered macrolide isolated from a marine-derived fungus, has been accomplished in a longest linear sequence of 15 steps from a chiral building block in 19% overall yield employing the 6-exo-trig transannular oxy-Michael reaction as the key step.