Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy†,10.1039/C0CC05781A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy†

Yui Furunaga,Keisuke Iida,Masayuki Tera,Kazuo Nagasawa,Kazunori Ikebukuro

Chemical Communications Pub Date : 05/05/2011 00:00:00 , DOI:10.1039/C0CC05781A

Abstract

The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex.