Expeditious syntheses of the tetrasaccharide cap related to the lipophosphoglycan of Leishmania donovani from two monosaccharides and a disaccharide building block were achieved by one-pot sequential glycosylation reactions. The monosaccharide building blocks were synthesized from D-mannose, and the disaccharide building block was prepared from lactose by C2-epimerisation of its glucose unit through C2 hydroxy oxidation–reduction.