Acylation or phosphorylation of hydroxyurea unexpectedly takes place on N rather than on O, leading to the formation of amides instead of the expected esters†,10.1039/C5RA01016K

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Acylation or phosphorylation of hydroxyurea unexpectedly takes place on N rather than on O, leading to the formation of amides instead of the expected esters†

Natalie Pariente-Cohen,Michal Weitman,Nassdyuk Tania,Dan T. Major,Hugo E. Gottlieb,Shmaryahu Hoz,Abraham Nudelman

RSC Advances Pub Date : 02/24/2015 00:00:00 , DOI:10.1039/C5RA01016K

Abstract

Attempted acylation of the anticancer agent hydroxyurea (HU) with acyl chlorides or anhydrides led to acylation on the NH group rather than on the OH. The structures of the products were confirmed by ¹⁵N-HMBC NMR. An analogous reaction conducted with hydroxamic acids (RCONHOH) or N-hydroxycarbamates (ROCONHOH) led to acylation on the OH. Surprisingly, despite the established affinity of phosphorous to O, phosphorylation of HU also took place at the NH group instead of the OH. These results are rationalized based on the different dominant resonance structures of HU, the hydroxamic acids or the N-hydroxycarbamates.