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Ascorbic acid promoted [4 + 2] benzannulation: a mild, operationally simple approach to the synthesis of phenanthrenes†
Mei-jie Bu,Guo-ping Lu,Chun Cai
Organic Chemistry Frontiers Pub Date : 03/21/2016 00:00:00 , DOI:10.1039/C6QO00020G
Abstract

A mild, simple and metal-free radical [4 + 2] benzannulation for the generation of phenanthrenes has been developed. A substoichiometric reductant, ascorbic acid (vitamin C), is harnessed as the radical initiator. This method has a broad substrate scope, and various substituted phenanthrenes were obtained in moderate to good yields at room temperature without irradiation.

Graphical abstract: Ascorbic acid promoted [4 + 2] benzannulation: a mild, operationally simple approach to the synthesis of phenanthrenes
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