Barriers to enantiocontrol in Lewis acid catalyzed hetero-Diels–Alder reactions†‡
Xiaochen Wang,Zhuoyan Li,Michael P. Doyle
Chemical Communications Pub Date : 08/26/2009 00:00:00 , DOI:10.1039/B913019E
Abstract
Lewis bases, including reactant aldehydes, inhibit the rate of conversion for cycloaddition and those, like aldehydes or nitriles, cause a decrease in enantiocontrol due to the Lewis acidity of the activated complex.
