Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720†,10.1039/C4RA02401J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720†

Hidemasa Hikawa,Maiko Hamada,Yuusaku Yokoyama,Isao Azumaya

RSC Advances Pub Date : 05/13/2014 00:00:00 , DOI:10.1039/C4RA02401J

Abstract

A novel and efficient method for the selective monobenzoylation of N-Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc)₂ and Cs₂CO₃ was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the monobenzoylation of 1,3-diols.