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Synthesis of Acyclonucleoside Derivatives of 5-Alkoxymethyluracils
Journal of Chemical Research, Synopses Pub Date : , DOI:10.1039/A802837K
Abstract

The silyl derivatives 3ac were treated with ethoxymethyl chloride (4a) or (2-acetoxyethoxy)methyl bromide (4b) to afford 5ac and 6ac, respectively; 7ac were prepared by treating 6ac with MeONa; treatment of 5ac or 6ac with tris(1H-1,2,4-triazole-1-yl)phosphine oxide and subsequent reaction of 8ac and 9ac with ammonia in dioxane to give 10ac and 11ac; ammonolysis of 11ac yielded the hydroxyalkyl derivatives 12ac.

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