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Benzylic ethers as arylcarboxy surrogates in substrate directed ortho C–H functionalisation catalysed by copper†
Nilufa Khatun,Arghya Banerjee,Sourav Kumar Santra,Wajid Ali,Bhisma K. Patel
RSC Advances Pub Date : 04/16/2015 00:00:00 , DOI:10.1039/C5RA03462K
Abstract

A copper catalysed ortho-benzoxylation of 2-arylpyridines has been accomplished using benzylic ethers as the alternative arylcarboxy sources (ArCOO–) via sp2 C–H bond activation. The use of the Pd/TBHP catalytic system is reported to install an o-aroyl (ArCO–) moiety at the 2-arylpyridine while the Cu/TBHP combination fixes a benzoxy (ArCOO–) group at the ortho site.

Graphical abstract: Benzylic ethers as arylcarboxy surrogates in substrate directed ortho C–H functionalisation catalysed by copper
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