A nano-carrier made of a norbornene derived isoniazid copolymer is designed. In vitro cytotoxicity assay and renal clearance analysis clearly indicate that the newly designed nano-carrier is biocompatible in nature. This nano-carrier with a hydrazone linker is shown to be a promising reservoir with excellent performance for an efficient drug delivery system. Moreover, the system also offers an effective strategy and new modalities for the development of TB therapy.