Graphene–CdS nanowire (NW) hybrid structures with high-speed photoconductivity were developed. The hybrid structure was comprised of CdS NWs which were selectively grown in specific regions on a single-layer graphene sheet. The photoconductive channels based on graphene–CdS NW hybrid structures exhibited much larger photocurrents than graphene-based channels and much faster recovery speed than CdS NW network-based ones. Our graphene–CdS NW structures can be useful because they were much faster than commercial CdS film-based photodetectors and had photocurrents large enough for practical applications.