The reduction of a series of crystalline mesoporous metal oxides, CeO₂, Co₃O₄, Cr₂O₃, CuO, β-MnO₂, Mn₃O₄, and NiO, was investigated using hydrogen temperature-programmed reduction (H₂-TPR). CeO₂ and Cr₂O₃ could not be reduced. Mesoporous Mn₃O₄ and NiO are reduced at almost the same temperature as their bulk counterparts, and mesoporous Co₃O₄, CuO, and β-MnO₂ are reduced at lower temperatures than the corresponding bulk materials. In particular, mesoporous Co₃O₄ and β-MnO₂ undergo reduction to CoO and Mn₃O₄ while preserving the mesostructure. Further reduction of CoO and Mn₃O₄, NiO, and CuO does not form mesoporous metal: in the case of CuO, a mesoporous intergrowth of Cu/Cu₂O is obtained, and for the rest metal oxides, particles are formed.