In this feature article, the applications of layered nanomaterials as green materials are demonstrated along with their structures and properties. Due to the unique 2-dimensional structures and biocompatibility, various eco- and bio-friendly materials can be hybridized with layered nanoparticles such as layered double hydroxides (LDHs), hydroxy double salts (HDSs) and cationic clays. From small molecules such as drugs, herbicides, fertilizers, and food ingredients to large substances like deoxyribonucelotides (DNA), protein, and enzymes, various functional materials can be incorporated into layered nanoparticles via intercalation reactions to produce green materials with versatile applications. The application fields of layered nanomaterials, especially LDHs, are summarized into three categories; biomolecule reservoir, pharmaceutical and other applications.