Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system†,10.1039/C8CY02377H

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system†

Jian-Dong Zhang,Xiao-Xiao Yang,Qiao Jia,Jian-Wei Zhao,Li-Li Gao,When-Chao Gao,Hong-Hong Chang,Wen-Long Wei,Jian-He Xu

Catalysis Science & Technology Pub Date : 12/04/2018 00:00:00 , DOI:10.1039/C8CY02377H

Abstract

A novel one-pot epoxide hydrolase/alcohol dehydrogenase/transaminase cascade process for the asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols is reported. The product (S)-β-amino alcohols were obtained in 97–99% ee and 79–99% conversion from readily available racemic epoxides.