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Asymmetric tandem Michael addition–ylide olefination reaction for the synthesis of optically active cyclohexa-1,3-diene derivatives†
Long-Wu Ye,Shou-Bing Wang,Qing-Gang Wang,Xiu-Li Sun,Yong Tang,Yong-Gui Zhou
Chemical Communications Pub Date : 04/15/2009 00:00:00 , DOI:10.1039/B900048H
Abstract

The reaction of a crotonate-derived chiral phosphonium salt with α,β-unsaturated carbonyl compounds in the presence of Cs2CO3 affords optically active cyclohexa-1,3-diene derivatives with up to 90% ee in good yields.

Graphical abstract: Asymmetric tandem Michael addition–ylide olefination reaction for the synthesis of optically active cyclohexa-1,3-diene derivatives
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