960化工网
Novel analgesics and molecular rearrangements in the morphine–thebaine group. Part IX. A novel aromatisation during Hofmann degradation
Journal of the Chemical Society C: Organic Pub Date : , DOI:10.1039/J39690002225
Abstract

Hofmann degradation of the methohydroxide of the thebainone-derived methine base (2) affords an optically active neutral product, (–)-1,2-dimethoxy-7-(4-hydroxy-2-isopropylphenyl)-8-vinylnaphthalene (12). At higher temperatures the racemate and its methyl ether are obtained. Structures were assigned to these products after consideration of their n.m.r. spectra. The mechanism of the rearrangement is discussed.

平台客服
平台客服
平台在线客服