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Highly diastereoselective synthesis of 2-monosubstituted 1R,5S(1S,5R)-glycoluriles on the basis of S- and R-N-carbamoyl-α-amino acids
Angelina N. Kravchenko,Konstantin Yu. Chegaev,Pavel A. Belyakov,Elena Yu. Maksareva,Konstantin A. Lyssenko,Oleg V. Lebedev,Nina N. Makhova
Mendeleev Communications Pub Date : , DOI:10.1070/MC2003v013n06ABEH001802
Abstract

The reactions of 4,5-dihydroxyimidazolidin-2-one with chiral S- and R-N-carbamoyl-α-amino acids occur diastereoselectively with the formation of corresponding 1R,5S(1S,5R)-glycoluriles as predominant diastereomers; the absolute configuration is determined for three stereoisomers by X-ray diffraction analysis.

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