Application of a metathesis reaction in the synthesis of sterically congested medium-sized rings. A direct ring closing versus a double bond migration–ring closing process†,10.1039/C1OB05086A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Application of a metathesis reaction in the synthesis of sterically congested medium-sized rings. A direct ring closing versus a double bond migration–ring closing process†

Michał Michalak,Jerzy Wicha

Organic & Biomolecular Chemistry Pub Date : 03/01/2011 00:00:00 , DOI:10.1039/C1OB05086A

Abstract

An efficient double bond migration–ring closing metathesis reaction leading to cycloheptene derivatives is observed when specific sterically congested 1,9-dienes are treated with the Grubbs' imidazolidene ruthenium catalyst. The simultaneous use of the Grubbs' catalyst and RuClH(CO)(PPh₃)₃ facilitates the tandem bond migration–metathesis process. RuClH(CO)(PPh₃)₃ alone is capable of triggering an unactivated double bond migration that may have preparative applications.