Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida†‡,10.1039/C6MD00365F

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Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida†‡

Matthew D. Stephens,Nisakorn Yodsanit,Christian Melander

MedChemComm Pub Date : 07/27/2016 00:00:00 , DOI:10.1039/C6MD00365F

Abstract

A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.