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Host–guest strategy to potently camouflage and restore the activity and toxicity of drugs affecting bacterial growth and viability†‡
J. Gravel,C. R. Elie,M. Khayat,A. Schmitzer
MedChemComm Pub Date : 03/30/2016 00:00:00 , DOI:10.1039/C6MD00109B
Abstract

We demonstrate the application of a controllable drug delivery system, where an active and toxic imidazolium salt can be camouflaged when assembled as an inclusion complex with cyclodextrins. The toxicity can be completely restored in the presence of a competitive non-toxic guest. The reversibility of this system is demonstrated both in living bacteria and human red blood cells.

Graphical abstract: Host–guest strategy to potently camouflage and restore the activity and toxicity of drugs affecting bacterial growth and viability
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