Synthesis of a novel thiophene derivative that induces cancer cell apoptosis through modulation of AKT and MAPK pathways†,10.1039/C2MD20041D

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis of a novel thiophene derivative that induces cancer cell apoptosis through modulation of AKT and MAPK pathways†

Yi Luo,Xiaoling Li,Tianfeng Chen,Yi Wang,Wenjie Zheng

MedChemComm Pub Date : 06/28/2012 00:00:00 , DOI:10.1039/C2MD20041D

Abstract

A novel thiophene-based compound N-(4′-hydroxyphenyl)-2,5-di(2′′-thienyl)pyrrole (SNS-OH) has been synthesized and evaluated for its in vitro anticancer activities. The results showed SNS-OH effectively induced apoptosis in neuroblastoma cells through regulating the AKT and MAPK pathways.